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Clinically important drug interactions Drugs that increase effectstoxicity of stavudine chloramphenicol, cisplatin, ethamb- utol, hydra- lazine, lithium, metronidazole, phenytoin, vincristine. Specific Lymphocyte-Signaling Inhibitors Cyclosporine and Tacrolimus The discovery in 1976 that cyclosporine (CsA; also referred to as cyclosporin A) is a specific inhibitor of T-cell-mediated immunity enabled widespread whole-organ transplantation.

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